Preimplantation genetic diagnosis significantly reduces pregnancy loss and increases take-home baby rate in poor prognosis patients
نویسندگان
چکیده
منابع مشابه
Will preimplantation genetic diagnosis assist patients with a poor prognosis to achieve pregnancy?
PGD (preimplantation genetic diagnosis) of aneuploidy for chromosomes X, Y, 13, 18 and 21 was carried out on 196 embryos from 36 infertile patients classified with a poor prognosis due to (i) maternal age, (ii) repeated in-vitro fertilization (IVF) failures and (iii) mosaic karyotype. The percentage of abnormal embryos was comparable in the three groups of patients: maternal age 63%, repeated I...
متن کاملPreimplantation genetic diagnosis for a couple with recurrent pregnancy loss and triploidy.
BACKGROUND Triploidy may arise from fertilization of a mature haploid egg by two haploid sperm or by failure of meiotic divisions yielding a diploid gamete. We encountered a couple with habitual abortion, in which the last two fetuses were documented as viable triploid. METHODS To avoid dispermic penetration and development of abnormal preembryos, insemination was done by intracytoplasmic spe...
متن کاملRecurrent First-trimester Pregnancy Loss: Is Preimplantation Genetic Diagnosis the Answer?
reimplantation genetic diagnosis (PGD) is a new test that can detect genetic abnormalities such as disease-causing mutations and chromosomal abnormalities to prevent the conception of an abnormal pregnancy or child. The use of PGD has made headlines recently in some controversial cases, such as in preventing the transmission of adult-onset diseases (eg, Alzheimer’s),1 and in helping a couple to...
متن کاملPreimplantation Genetic Diagnosis
Inherited genetic diseases have been a problem for some families attempting to conceive a child. If affected parents or carriers of genetic disorders wished to avoid transmitting a condition to their child, they can choose to have prenatal diagnosis of their foetus. Amniocentesis or chorionic villus sampling enables cells from the foetus to be collected and sent for genetic analysis. They could...
متن کاملPreimplantation Genetic Diagnosis (PGD)
Preimplantation genetic diagnosis (PGD) is a reproductive technology used with an in vitro fertilization (IVF) cycle to increase the potential for a successful pregnancy and delivery. The most common applications for PGD include testing for extra or missing chromosomes (aneuploidy screening), familial structural chromosome rearrangements, and diagnosis of genetic disease in couples of increased...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2008
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)61352-1